The contraction of smooth muscle is an essential process underpinning diverse physiological functions ranging from gastrointestinal motility to vascular regulation. At its core, smooth muscle ...
HOUSTON – (July 10, 2023) – One of the main ways cells “talk” to each other to coordinate essential biological activities such as muscle contraction, hormone release, neuronal firing, digestion and ...
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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
The molecule-sized devices activated the same calcium-based cellular signaling mechanism in a live organism, causing whole-body contraction in a fresh-water polyp, or Hydra vulgaris. "This is the ...
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