1 day ago · Here’s everything you need to know from the San Francisco 49ers' 48-27 win over the Indianapolis Colts on Monday at Lucas Oil Stadium.

1 day ago · The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers …

1 day ago · The San Francisco 49ers have officially put their playoff destiny in their own hands. With a 48-27 win over the Indianapolis Colts on "Monday Night Football," San Francisco will not have to …

18 hours ago · Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

Dec 24, 2025 · 49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip Rivers' season debut at home in 48-27 win Bills, Jaguars and Chargers clinch playoff spots on Colts' defeat Story by

19 hours ago · Here's what to know from the 49ers' win over the Colts on Monday night.

19 hours ago · 49ers vs. Colts takeaways: Brock Purdy’s 5 TDs put Philip Rivers, Indy on the brink Brock Purdy's career-high five touchdown passes kept the 49ers in the hunt to claim the NFC's top …

17 hours ago · The San Francisco 49ers pulled away from the Indianapolis Colts to continue their improbable 2025 run. Here are the takeaways.

3 days ago · NFL 49ers 48 vs. 27 Colts summary, stats, score and highlights | NFL Week 16 Brock Purdy threw for five TDs in a Monday Night shootout as the San Francisco 49ers beat the …

12 hours ago · 49ers report card: Offense just keeps churning in win over Colts 49ers rack up touchdowns as Brock Purdy plays point guard, hooking up with four receivers for five scores